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The Conscious Style Guide

The Conscious Style Guide

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A Note From the Founder

I’m bothered by the lack of distinction between generative AI and non-generative AI (also called traditional machine learning, traditional AI, analytical AI) in nearly all AI coverage and commentary.

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Collapsing different types of AI into one term, “AI,” promotes confusion and misinformation about what we really need to pay attention to and be concerned about. When products, for example, are described as “using AI” or “having AI,” it tells me nothing about what is actually being used or whether there are ethical issues involved, e.g., theft of creators’ works by gen AI.

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Synthetic sugar-coated nanoparticle blocks Covid-19 from infecting human cells

Synthetic sugar-coated nanoparticle blocks Covid-19 from infecting human cells

Groundbreaking research led by a Swansea University academic has revealed a synthetic glycosystem – a sugar-coated polymer nanoparticle – that can block Covid-19 from infecting human cells, reducing infection rates by nearly 99%.

The glycosystem is a specially designed particle that mimics natural sugars found on human cells. These sugars, known as polysialosides, are made of repeating units of sialic acid – structures that viruses often target to begin infection. By copying this structure, the synthetic molecule acts as a decoy, binding to the virus’s spike protein and preventing it from attaching to real cells.

Unlike vaccines, which trigger immune responses, this molecule acts as a physical shield, offering a novel approach to infection prevention.

Using advanced lab techniques to measure molecular interactions and simulate virus binding, researchers found that the glycosystem binds to the virus 500 times more strongly than a similar compound containing sulphates but no sugars. It was also effective at very low doses and worked against both the original SARS-CoV-2 strain and the more infectious D614G variant.

Tests on human lung cells showed a 98.6% reduction in infection when the molecule was present. Crucially, the research highlighted that its effectiveness stems not just from its charge, but from its precise sugar structure – giving this glycosystem its powerful infection-blocking capability.

The discovery is the result of collaboration between Swansea University, Freie Universität Berlin, and Charité – Universitätsmedizin Berlin.

Ultimate guide to the essential tools for the characterization of proteins, polymers and nanoparticles eBook Compilation of the top interviews, articles, and news in the last year.Download the latest edition

As the main corresponding author and research supervisor, Dr Sumati Bhatia, Senior Lecturer in Chemistry at Swansea University, said: “Leading this research, alongside our international partners, has been incredibly rewarding. It opens a new direction for using glycosystems as a therapeutic strategy against SARS-CoV-2 and could lay the foundation for a new class of antiviral therapies to protect those most at risk.”

The team is now preparing for further biological testing in high-containment laboratories to assess the molecule’s effectiveness against multiple virus strains.

T

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his breakthrough could pave the way for antiviral nasal sprays, surface disinfectants, and treatments to protect vulnerable groups, offering a new line of defense against Covid-19 and future pandemics.

Source:

Swansea University

Journal reference:

Khatri, V., et al. (2025). Polysialosides Outperform Sulfated Analogs for Binding with SARS-CoV-2. Small. doi.org/10.1002/smll.202500719.

Synthetic sugar-coated nanoparticle blocks Covid-19 from infecting human cells

Synthetic sugar-coated nanoparticle blocks Covid-19 from infecting human cells

Groundbreaking research led by a Swansea University academic has revealed a synthetic glycosystem – a sugar-coated polymer nanoparticle – that can block Covid-19 from infecting human cells, reducing infection rates by nearly 99%.

The glycosystem is a specially designed particle that mimics natural sugars found on human cells. These sugars, known as polysialosides, are made of repeating units of sialic acid – structures that viruses often target to begin infection. By copying this structure, the synthetic molecule acts as a decoy, binding to the virus’s spike protein and preventing it from attaching to real cells.

Unlike vaccines, which trigger immune responses, this molecule acts as a physical shield, offering a novel approach to infection prevention.

Using advanced lab techniques to measure molecular interactions and simulate virus binding, researchers found that the glycosystem binds to the virus 500 times more strongly than a similar compound containing sulphates but no sugars. It was also effective at very low doses and worked against both the original SARS-CoV-2 strain and the more infectious D614G variant.

Tests on human lung cells showed a 98.6% reduction in infection when the molecule was present. Crucially, the research highlighted that its effectiveness stems not just from its charge, but from its precise sugar structure – giving this glycosystem its powerful infection-blocking capability.

The discovery is the result of collaboration between Swansea University, Freie Universität Berlin, and Charité – Universitätsmedizin Berlin.

Ultimate guide to the essential tools for the characterization of proteins, polymers and nanoparticles eBook Compilation of the top interviews, articles, and news in the last year.Download the latest edition

As the main corresponding author and research supervisor, Dr Sumati Bhatia, Senior Lecturer in Chemistry at Swansea University, said: “Leading this research, alongside our international partners, has been incredibly rewarding. It opens a new direction for using glycosystems as a therapeutic strategy against SARS-CoV-2 and could lay the foundation for a new class of antiviral therapies to protect those most at risk.”

The team is now preparing for further biological testing in high-containment laboratories to assess the molecule’s effectiveness against multiple virus strains.

T

Thanks for reading Capturing Voices! Subscribe for free to receive new posts and support my work.

his breakthrough could pave the way for antiviral nasal sprays, surface disinfectants, and treatments to protect vulnerable groups, offering a new line of defense against Covid-19 and future pandemics.

Source:

Swansea University

Journal reference:

Khatri, V., et al. (2025). Polysialosides Outperform Sulfated Analogs for Binding with SARS-CoV-2. Small. doi.org/10.1002/smll.202500719.

Scientists Identify a Trait in Speech That Foreshadows Cognitive Decline

Scientists Identify a Trait in Speech That Foreshadows Cognitive Decline

Could the way we speak reveal what’s happening in our brains? In article, science writer Carly Cassella dives into new research showing that slower speech might be an early sign of cognitive decline — even before memory issues show up. Using AI to analyze speech from people across a wide age range, researchers found a strong link between speaking speed and brain health. It’s a thought-provoking read, especially for anyone interested in aging, neuroscience, or just how much our words might say about us.

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Early signs of Alzheimer’s disease may be hidden in the way a person speaks, but it’s not yet clear which details of our diction are most critical for diagnosis.

A study from 2023 suggests that as we age, how we say something may matter more than what we say. Researchers at the University of Toronto think the pace of everyday speech may be a better indicator of cognitive decline than difficulty finding a word.

Lethologica, also known as ‘tip of the tongue‘ phenomenon, is experienced by young and old alike. But as we grow older, finding the name for things can become more challenging, especially over the age of 60.

To explore why that is, researchers at the University of Toronto asked 125 healthy adults, between the ages of 18 and 90, to describe a scene in detail.

Next, the participants were shown pictures of everyday objects while listening to audio that was designed to confirm or confuse them.

For instance, if participants were shown a picture of a broom, the audio might say ‘groom’, which helps them recall the word through rhyme. But on the flip side, the audio might also offer a related word like ‘mop’, which can lead the brain astray, momentarily.

The faster a person’s natural speech in the first task, the more quickly they came up with answers in the second task.

The findings align with the ‘processing speed theory’, which argues that a general slowdown in cognitive processing lies at the very center of cognitive decline, not a slowdown in memory centers specifically.

“It is clear that older adults are significantly slower than younger adults in completing various cognitive tasks, including word-production tasks such as picture naming, answering questions, or reading written words,” explained a team led by University of Toronto psychologist Hsi T. Wei.

“In natural speech, older adults also tend to produce more dysfluencies such as unfilled and filled pauses (e.g., “uh” and “um”) in between speech and have a generally slower speech rate.”

In a 2024 piece for The Conversation, dementia researcher Claire Lancaster said that the study from Toronto “has opened exciting doors… showing that it’s not just what we say but how fast we say it that can reveal cognitive changes.”

Recently, some AI algorithms have even been able to predict an Alzheimer’s diagnosis with an accuracy of 78.5 percent using speech patterns alone.

Other studies have found that patients with more signs of amyloid plaque in their brain are 1.2 times more likely to show speech-related problems.

Amyloid plaques are a hallmark of Alzheimer’s disease.

In 2024, researchers at Stanford University led a study that found longer pauses and slower speech rates were also associated with higher levels of tangled tau proteins, another hallmark of Alzheimer’s.

“This suggests that speech changes reflect development of Alzheimer’s disease pathology even in the absence of overt cognitive impairment,” the authors of the study concluded.

The groundwork is still being laid, but scientists are getting closer to decoding the nuances of human speech to figure out what our words are saying about our brains.

The 2023 study was published in Aging, Neuropsychology, and Cognition.

Thanks for reading Capturing Voices! Subscribe for free to receive new posts and support my work.

Scientists Identify a Trait in Speech That Foreshadows Cognitive Decline

Scientists Identify a Trait in Speech That Foreshadows Cognitive Decline

Could the way we speak reveal what’s happening in our brains? In article, science writer Carly Cassella dives into new research showing that slower speech might be an early sign of cognitive decline — even before memory issues show up. Using AI to analyze speech from people across a wide age range, researchers found a strong link between speaking speed and brain health. It’s a thought-provoking read, especially for anyone interested in aging, neuroscience, or just how much our words might say about us.

Thanks for reading Capturing Voices! Subscribe for free to receive new posts and support my work.

Early signs of Alzheimer’s disease may be hidden in the way a person speaks, but it’s not yet clear which details of our diction are most critical for diagnosis.

A study from 2023 suggests that as we age, how we say something may matter more than what we say. Researchers at the University of Toronto think the pace of everyday speech may be a better indicator of cognitive decline than difficulty finding a word.

Lethologica, also known as ‘tip of the tongue‘ phenomenon, is experienced by young and old alike. But as we grow older, finding the name for things can become more challenging, especially over the age of 60.

To explore why that is, researchers at the University of Toronto asked 125 healthy adults, between the ages of 18 and 90, to describe a scene in detail.

Next, the participants were shown pictures of everyday objects while listening to audio that was designed to confirm or confuse them.

For instance, if participants were shown a picture of a broom, the audio might say ‘groom’, which helps them recall the word through rhyme. But on the flip side, the audio might also offer a related word like ‘mop’, which can lead the brain astray, momentarily.

The faster a person’s natural speech in the first task, the more quickly they came up with answers in the second task.

The findings align with the ‘processing speed theory’, which argues that a general slowdown in cognitive processing lies at the very center of cognitive decline, not a slowdown in memory centers specifically.

“It is clear that older adults are significantly slower than younger adults in completing various cognitive tasks, including word-production tasks such as picture naming, answering questions, or reading written words,” explained a team led by University of Toronto psychologist Hsi T. Wei.

“In natural speech, older adults also tend to produce more dysfluencies such as unfilled and filled pauses (e.g., “uh” and “um”) in between speech and have a generally slower speech rate.”

In a 2024 piece for The Conversation, dementia researcher Claire Lancaster said that the study from Toronto “has opened exciting doors… showing that it’s not just what we say but how fast we say it that can reveal cognitive changes.”

Recently, some AI algorithms have even been able to predict an Alzheimer’s diagnosis with an accuracy of 78.5 percent using speech patterns alone.

Other studies have found that patients with more signs of amyloid plaque in their brain are 1.2 times more likely to show speech-related problems.

Amyloid plaques are a hallmark of Alzheimer’s disease.

In 2024, researchers at Stanford University led a study that found longer pauses and slower speech rates were also associated with higher levels of tangled tau proteins, another hallmark of Alzheimer’s.

“This suggests that speech changes reflect development of Alzheimer’s disease pathology even in the absence of overt cognitive impairment,” the authors of the study concluded.

The groundwork is still being laid, but scientists are getting closer to decoding the nuances of human speech to figure out what our words are saying about our brains.

The 2023 study was published in Aging, Neuropsychology, and Cognition.

Thanks for reading Capturing Voices! Subscribe for free to receive new posts and support my work.